Автор: Administrator
Четверг, 21 марта 2013, 18.00
МГУ, Лаб. корпус Б (факультет биоинженерии и биоинформатики), к. 221.
Prof. Dr. Edgar Wingender
University Medical Center Goettingen and geneXplain GmbH, Germany
Constructions and analysis of gene regulatory networks
Gene
regulatory networks comprising transcriptional and post-transcriptional
events may provide a useful tool for characterizing regulatory
processes of a cell with systems biological approaches. Using
bioinformatic approaches for two independent criteria (predicted
affinity and multi-genome conservativity), we have constructed the core
of a transcriptional network for human cells. This network was expanded
(a) by paralogous TF-target gene relations, based on a comprehensive
transcription factor classification, and (b) by predicted and known
microRNA-target gene relations. From the resulting gene regulatory
reference network, a number of tissue-specific subnetworks could be
extracted. They revealed structural particularities that seem to be
characteristic for the different tissues.
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